Background High-risk febrile neutropenia (HR-FN) is a life-threatening complication in
patients with haematological malignancies or receiving myelosuppressive chemotherapy …

Antibiotic development traditionally involved large Phase 3 programs, preceded by Phase 2
studies. Recognizing the high unmet medical need for new antibiotics and, in some cases …

Objective This study measured the effect of renal function on the plasma concentrations of
ceftazidime and avibactam in critically ill patients. We also sought to measure the …

An estimated 70% of critically ill patients receive antibiotics, most frequently beta-lactams.
The pharmacokinetic properties of these substances in this patient population are poorly …

Antimicrobial dosing can be a complex challenge. Although a solid rationale exists for a link
between antibiotic exposure and outcome, conflicting data suggest a poor correlation …

(1) Background: Knowledge about the behavior of antibiotics in critically ill patients has been
increasing in recent years. Some studies have concluded that a high percentage may be …

Monitoring plasma concentrations of β-lactam antibiotics is crucial, particularly in critically ill
patients, where variations in concentrations can lead to treatment failure or adverse events …

Materials and Methods: Samples were collected from small animal hospitals in Surat Thani,
Nakhon Si Thammarat, and Songkhla in Thailand. Hospitals were defined as those that had …

Introduction Antibiotic concentration target attainment is known to be poor in critically ill
patients. Dose adjustment is recommended in patients with altered clearance, obesity and …

Background: Current antibiotic regimens for infective endocarditis (IE) are effective but pose
a high risk of delayed hypersensitivity reactions (DHR). Dose adjustments guided by …