A brief review of the biological potential of indole derivatives
S Kumar, Ritika - Future Journal of Pharmaceutical Sciences, 2020 - Springer
Background Various bioactive aromatic compounds containing the indole nucleus showed
clinical and biological applications. Indole scaffold has been found in many of the important …
clinical and biological applications. Indole scaffold has been found in many of the important …
Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008–2019)
Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …
biological functions especially in the mechanism of pain and inflammation, among other …
Recent advancements in the development of heterocyclic anti-inflammatory agents
Most of the anti-inflammatory drugs in clinical practice are becoming outdated owing to their
potential side and adverse effects. These are found to be highly unsafe for long term use …
potential side and adverse effects. These are found to be highly unsafe for long term use …
The indole nucleus as a selective COX-2 inhibitor and anti-inflammatory agent (2011–2022)
Here we have outlined the recent (2011–2022) developments in the synthesis of modified
indomethacin-based analogues for the selective inhibition of COX-2 and then highlighted …
indomethacin-based analogues for the selective inhibition of COX-2 and then highlighted …
Optimization of pyrazole-based compounds with 1, 2, 4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis …
The cardiovascular side effects associated with COX-2 selective drugs were the worst for
coxibs leading to their withdrawal from the market a few years after their discovery …
coxibs leading to their withdrawal from the market a few years after their discovery …
Recent developments by zinc based reagents/catalysts promoted organic transformations
The Lewis acids of the sort ZnX 2 (X= Cl, Br, OTf & I) are rather simple and mild yet proves its
efficiency in enabling wide range of synthetic transformations in organic synthesis …
efficiency in enabling wide range of synthetic transformations in organic synthesis …
Polysaccharides from Agave salmiana bagasse improves the storage stability and the cellular uptake of indomethacin nanoemulsions
A Jiménez-Rodríguez, E Heredia-Olea… - Food and Bioproducts …, 2021 - Elsevier
Agave salmiana is one of the most used agave species to produce aguamiel, but once the
aguamiel extraction is done, agave bagasse is discarded or used as animal feed. Agave …
aguamiel extraction is done, agave bagasse is discarded or used as animal feed. Agave …
Indole-based COX-2 inhibitors: A decade of advances in inflammation, cancer, and Alzheimer's therapy
Abstract Cyclooxygenase-2 (COX-2), a key enzyme in the cyclooxygenase family, is pivotal
in producing pro-inflammatory prostaglandins, driving chronic inflammation and related …
in producing pro-inflammatory prostaglandins, driving chronic inflammation and related …
Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on celecoxib scaffold supported with in vivo anti-inflammatory …
Abstract Four new series of 1, 2, 4 triazole derivatives 4a, b 5a-d, 6a-f, and 7a, b possessing
methylsulphonylphenyl moiety as COX-2 pharmacophore were designed and synthesized …
methylsulphonylphenyl moiety as COX-2 pharmacophore were designed and synthesized …
New indomethacin analogs as selective COX‐2 inhibitors: Synthesis, COX‐1/2 inhibitory activity, anti‐inflammatory, ulcerogenicity, histopathological, and docking …
KRA Abdellatif, EKA Abdelall… - Archiv der …, 2021 - Wiley Online Library
New indomethacin analogs 4a–g, 5, 6, 8a, and 8b were synthesized to overcome the
nonselectivity and ulcer liability of indomethacin. All newly synthesized compounds were …
nonselectivity and ulcer liability of indomethacin. All newly synthesized compounds were …