The role of autophagy in bone metabolism and clinical significance

J Wang, Y Zhang, J Cao, Y Wang, N Anwar, Z Zhang… - Autophagy, 2023 - Taylor & Francis
The skeletal system is the basis of the vertebral body composition, which affords stabilization
sites for muscle attachment, protects vital organs, stores mineral ions, supplies places to the …

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives

S Regmi, S Pathak, JO Kim, CS Yong… - European journal of cell …, 2019 - Elsevier
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …

[HTML][HTML] Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling

S Lorzadeh, L Kohan, S Ghavami, N Azarpira - Biochimica et Biophysica …, 2021 - Elsevier
Cellular homeostasis and adaptation to various environmental conditions are importantly
regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling …

Autophagy in bone homeostasis and the onset of osteoporosis

X Yin, C Zhou, J Li, R Liu, B Shi, Q Yuan, S Zou - Bone research, 2019 - nature.com
Autophagy is an evolutionarily conserved intracellular process, in which domestic cellular
components are selectively digested for the recycling of nutrients and energy. This process …

Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies

HR Hofer, RS Tuan - Stem cell research & therapy, 2016 - Springer
Adult mesenchymal stem cells (MSCs) represent a subject of intense experimental and
biomedical interest. Recently, trophic activities of MSCs have become the topic of a number …

[HTML][HTML] Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine

A González-González, D García-Sánchez… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are the most frequently used stem cells in clinical trials due
to their easy isolation from various adult tissues, their ability of homing to injury sites and …

The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells

Q Li, Z Gao, Y Chen, MX Guan - Protein & cell, 2017 - Springer
Mesenchymal stem cells (MSCs) are progenitors of connective tissues, which have emerged
as important tools for tissue engineering due to their differentiation potential along various …

The role and mechanism of mitochondrial functions and energy metabolism in the function regulation of the mesenchymal stem cells

W Yan, S Diao, Z Fan - Stem Cell Research & Therapy, 2021 - Springer
Mesenchymal stem cells (MSCs) are multipotent cells that show self-renewal, multi-
directional differentiation, and paracrine and immune regulation. As a result of these …

Autophagy: a potential key contributor to the therapeutic action of mesenchymal stem cells

S Ceccariglia, A Cargnoni, AR Silini, O Parolini - Autophagy, 2020 - Taylor & Francis
Macroautophagy/autophagy occurs at basal levels in all eukaryotic cells and plays an
important role in maintaining bio-energetic homeostasis through the control of molecule …

Gold nanoparticles targeting the autophagy–lysosome system to combat the inflammation-compromised osteogenic potential of periodontal ligament stem cells: from …

Y Yin, BM Tian, X Li, YC Yu, DK Deng, LJ Sun, HL Qu… - Biomaterials, 2022 - Elsevier
Although substantial data indicate that the osteogenic potential of periodontal ligament stem
cells (PDLSCs) is compromised under inflammatory conditions, the underlying mechanism …