In this study, we focused on innovative approaches to improve drug administration in oral
pathology, especially by transmucosal and transdermal pathways. These improvements …

Transcriptomic, metabolomic, physiological, and computational modeling approaches were
integrated to gain insight into the mechanisms of antibiotic tolerance in an in vitro biofilm …

Bacteria depend on a well-regulated iron homeostasis to survive adverse environments. A
key component of the iron homeostasis machinery is the compartmentalization of Fe3+ in …

Staphylococcus aureus biofilms are poorly responsive to antibiotics. Underlying reasons
include a matrix effect preventing drug access to embedded bacteria, or the presence of …

Is there a universal genetically programmed defense providing tolerance to antibiotics when
bacteria grow as biofilms? A comparison between biofilms of three different bacterial …

Bacterial non-coding RNAs (ncRNAs) play important regulatory roles in various
physiological metabolic pathways. In this study, a novel ncRNA CsiR (ciprofloxacin stress …

Animal models of chronic lung infection with P. aeruginosa (PA) are useful tools to improve
antibiotic (ATB) treatment. Two main models based on the pulmonary instillation of PA …

Understanding the evolution of antibiotic resistance is important for combating drug-resistant
bacteria. In this work, we investigated the adaptive response of Pseudomonas aeruginosa to …

Atopic dermatitis (AD) is a chronic inflammatory skin disease where patients are more
susceptible to infection and inflammation. The most salient symptoms of atopic dermatitis …

It is well documented that biofilms have inherent tolerance to killing and removal by
biocides, antibiotics, and the innate immune system. While the matrix may impede …