Abstract Leishmaniasis is a Neglected Tropical Diseases caused by protozoan parasites of
the genus Leishmania. It is a major health problem in many tropical and subtropical regions …

Boldo leaves (Boldo folium, from Peumus boldus Mol.) are very frequently used as a
medicinal herb in Chile and are exported to many countries to be used in teas or as extracts …

The antileishmanial activity of the essential oil (EO) from Chenopodium ambrosioides L. has
been demonstrated in vitro and in animal models, attributed to the major components of the …

The worldwide presence of Leishmania parasites increases in the poorest regions. Current
leishmaniasis treatments are unsatisfactory due to resistance development, side effects and …

Endoperoxides kill malaria parasites via cleavage of their endoperoxide bridge by haem or
iron, leading to generation of cytotoxic oxygen-centred radicals. In view of the Leishmania …

Leishmaniases are neglected diseases that can be treated with a limited drug arsenal; the
development of new molecules is therefore a priority. Recent evidence indicates that …

Bridged 1, 2, 4, 5-tetraoxanes were prepared using available acidic ion exchange resin with
high yields despite the possibility of peroxide decomposition under heterogeneous …

Active principles found in plants may aid in antiparasitic treatments, however it is important
to evaluate if they do not have cytotoxicity. The leishmanicidal and trypanocidal activities of …

Endoperoxides (EPs) appear to be promising drug candidates against protozoal diseases,
including malaria and leishmaniasis. Previous studies have shown that these drugs need an …

Background The discovery of artemisinin, an endoperoxide, encouraged the scientific
community to explore endoperoxides as potential anti-parasitic molecules. Although …