Exploring the recent pioneering developments of small molecules in antimalarial drug armamentarium: A chemistry prospective appraisal

T Bagratee, R Prawlall, T Ndlovu, S Sibisi… - Chemistry & …, 2024 - Wiley Online Library
Malaria is a very destructive and lethal parasitic disease that causes significant mortality
worldwide, resulting in the loss of millions of lives annually. It is an infectious disease …

Novel Para-Aminobenzoic Acid Analogs and Their Potential Therapeutic Applications

F Haroon, U Farwa, M Arif, MA Raza, ZA Sandhu… - Biomedicines, 2023 - mdpi.com
A “building block” is a key component that plays a substantial and critical function in the
pharmaceutical research and development industry. Given its structural versatility and ability …

Hybrid PABA‐glutamic acid conjugated 1,3,5‐triazine derivatives: Design, synthesis, and antimalarial activity screening targeting Plasmodium falciparum dihydro …

AAK Choudhury, S Vinayagam… - Chemical Biology & …, 2023 - Wiley Online Library
Despite the successful reduction in the malaria health burden in recent years, it continues to
remain a significant global health problem mainly because of the emerging resistance to first …

Molecular docking and antimalarial evaluation of novel N-(4-aminobenzoyl)-l-glutamic acid conjugated 1,3,5-triazine derivatives as Pf-DHFR inhibitors

N Adhikari, AAK Choudhury, A Shakya, SK Ghosh… - 3 Biotech, 2022 - Springer
Malaria has been a source of concern for humans for millennia; therefore in the present
study we have utilized in-silico approach to generate diverse anti-malarial hit. Towards this …

Unlocking nitrogen compounds' promise against malaria: A comprehensive review

PV Kuthe, M Muzaffar‐Ur‐Rehman… - Archiv der …, 2024 - Wiley Online Library
Plasmodium parasites are the primary cause of malaria, leading to high mortality rates,
which require clinical attention. Many of the medications used in the treatment have resulted …

[HTML][HTML] Pyrimidine and cumene derivatives functionalized by hydroxy and methoxy: Computational insights in drug-likeness, ADM, and toxicity studies

G Serdaroğlu, E Soyutek, Ş Koçarslan, C Uludağ - Results in Chemistry, 2023 - Elsevier
The–OH and–OCH 3 functionalized isopropyl cumene and isopropyl pyrimidine derivatives
were designed and, explored in terms of the ADM, and possible toxic effects in view of the …

Virtual Screening, Synthesis, and Antimalarial Profiling of PABA-Glutamic Acid Linked 1, 3, 5-Triazine Hybrids

AAK Choudhury, S Vinayagam, N Adhikari… - Journal of Molecular …, 2025 - Elsevier
Malaria parasites have demonstrated a remarkable ability to develop resistance to
antimalarial drugs and malaria continues to be a major global health burden, necessitating …

Target-Based 6-5 Fused Ring Heterocyclic Scaffolds Display Broad Antiparasitic Potency In Vitro

D Dize, MBT Tali, CAN Ngansop, R Keumoe… - Future …, 2024 - mdpi.com
Malaria, leishmaniasis, and African trypanosomiasis are protozoan diseases that constitute
major global health problems, especially in developing countries; however, the development …