Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Methods for acquiring spatially resolved omics data from complex tissues use barcoded
DNA arrays of low-to sub-micrometer features to achieve single-cell resolution. However …

The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic
agents to treat neuropathic pain,. However, development of analgesic orthosteric A1R …

The nature of the transition from acute to chronic pain still eludes explanation, but chronic
pain resulting from surgery provides a natural experiment that invites clinical …

Reciprocal signalling between immunocompetent cells in the central nervous system (CNS)
has emerged as a key phenomenon underpinning pathological and chronic pain …

A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …

Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …

Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory system. It is generally chronic and challenging to treat. The recommended …

We applied and validated a quantitative allodynia assessment technique, using a recently
developed rat surgical neuropathy model wherein nocifensive behaviors are evoked by light …