Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …

An overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives

L Schirone, M Forte, L D'Ambrosio, V Valenti… - Cells, 2022 - mdpi.com
Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …

Pericardial Delivery of SDF‐1α Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling

L Luo, Y Li, Z Bao, D Zhu, G Chen, W Li… - Advanced …, 2024 - Wiley Online Library
The stromal‐derived factor 1α/chemokine receptor 4 (SDF‐1α/CXCR4) axis contributes to
myocardial protection after myocardial infarction (MI) by recruiting endogenous stem cells …

hESCs‐derived early vascular cell spheroids for cardiac tissue vascular engineering and myocardial infarction treatment

Y Liu, Y Zhang, T Mei, H Cao, Y Hu, W Jia… - Advanced …, 2022 - Wiley Online Library
Transplanting functional cells to treat myocardial infarction (MI), a major disease threatening
human health, has become the focus of global therapy. However, the efficacy has not been …

Hybrid SMART spheroids to enhance stem cell therapy for CNS injuries

C Rathnam, L Yang, S Castro-Pedrido, J Luo, L Cai… - Science …, 2021 - science.org
Although stem cell therapy holds enormous potential for treating debilitating injuries and
diseases in the central nervous system, low survival and inefficient differentiation have …

hiPSC-derived cardiac tissue for disease modeling and drug discovery

J Li, Y Hua, S Miyagawa, J Zhang, L Li, L Liu… - International journal of …, 2020 - mdpi.com
Relevant, predictive normal, or disease model systems are of vital importance for drug
development. The difference between nonhuman models and humans could contribute to …

Targeting the redox system for cardiovascular regeneration in aging

MS Allemann, P Lee, JH Beer, SS Saeedi Saravi - Aging Cell, 2023 - Wiley Online Library
Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …

Recent advances in cardiac tissue engineering for the management of myocardium infarction

V Sharma, SK Dash, K Govarthanan, R Gahtori, N Negi… - Cells, 2021 - mdpi.com
Myocardium Infarction (MI) is one of the foremost cardiovascular diseases (CVDs) causing
death worldwide, and its case numbers are expected to continuously increase in the coming …

Mesenchymal stromal cells overexpressing farnesoid X receptor exert cardioprotective effects against acute ischemic heart injury by binding endogenous bile acids

Y Xia, X Xu, Y Guo, C Lin, X Xu, F Zhang… - Advanced …, 2022 - Wiley Online Library
Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules
that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC) …

Adult Multipotent Cardiac Progenitor-Derived Spheroids: A Reproducible Model of In Vitro Cardiomyocyte Commitment and Specification

M Scalise, F Marino, L Salerno, N Amato, C Quercia… - Cells, 2023 - mdpi.com
Background: Three-dimensional cell culture systems hold great promise for bridging the gap
between in vitro cell-based model systems and small animal models to study tissue biology …