Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

In this review, we discuss recent advances made on histone methylation and its diverse
functions in regulating gene expression. Methylation of histone polypeptides might be static …

The assembly of higher order chromatin structures has been linked to the covalent
modifications of histone tails. We provide in vivo evidence that lysine 9 of histone H3 (H3 …

In response to the emergence of pathogenic bacteria that cannot be treated with current
antibiotics, many researchers are revisiting the use of bacteriophages, or phages, to fight …

Eukaryotic DNA is organized into structurally distinct domains that regulate gene expression
and chromosome behavior. Epigenetically heritable domains of heterochromatin control the …

Chromatin, which consists of DNA and associated proteins, contains genetic information and
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …

Faithful transfer of parental histones to newly replicated daughter DNA strands is critical for
inheritance of epigenetic states. Although replication proteins that facilitate parental histone …

The higher-order assembly of chromatin imposes structural organization on the genetic
information of eukaryotes and is thought to be largely determined by posttranslational …

Recent results from diverse organisms point to a self-reinforcing network of interactions
among the three best-characterized covalent modifications that mark heterochromatin …

Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …