As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …

Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2) and
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …

Metallic radionuclides possess a variety of half-lives, emission types, energies, and
branching ratios, making it possible to apply them as diagnostic and/or therapeutic agents …

The involvement of copper in numerous physiological processes makes this metal ion
essential for human life. Alterations in copper homeostasis might have deleterious …

Degeneration and death of motor neurons in Amyotrophic Lateral Sclerosis (ALS) are
associated with increased lipid peroxidation. Lipid peroxidation is the driver of ferroptosis …

Background and Purpose Diacetyl‐bis (4‐methyl‐3‐thiosemicarbazonato) copperII (CuII
(atsm)) ameliorates neurodegeneration and delays disease progression in mouse models of …

Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates
hundreds of antioxidant genes, and is activated in response to oxidative stress. Given that …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by
progressive loss of muscle function. It is the most common adult‐onset form of motor neuron …