Natural killer (NK) cells have been implicated in tumour surveillance and in the early control
of several microbial infections. In autoimmune disease their involvement in these processes …

Most consensus leukemia & lymphoma antibody panels consist of lists of markers based on
expert opinions, but they have not been validated. Here we present the validated EuroFlow …

Abstract Large Granular Lymphocyte (LGL) Leukemia is a rare, heterogeneous even more
that once thought, chronic lymphoproliferative disorder characterized by the clonal …

Distinguishing chronic lymphoproliferative disorders of NK cells (CLPD-NK) from reactive
NK-cell expansion is challenging. We assessed the value of killer immunoglobulin-like …

The JAK/STAT pathway is altered in T-cell large granular lymphocytic leukemia. In all
patients, leukemic LGLs display upregulation of phosphorylated STAT3 (P-STAT3) that …

Natural killer (NK) cells are advantaged innate cytotoxic lymphocytes with characteristics of
tumor immunosurveillance and microorganism elimination. Distinguish from the adaptive T …

Although NK cells are considered part of the innate immune system, a series of evidences
has demonstrated that they possess characteristics typical of the adaptive immune system …

Tlarge granular lymphocyte leukemia (T-LGLL) is characterized by the expansion of several
large granular lymphocyte clones, among which a subset of large granular lymphocytes …

ABSTRACT Background The 2008 World Health Organization (WHO) classification
distinguishes three entities among the large granular lymphocytic leukemia (LGL leukemia) …

Cancer immunotherapies are preferred over conventional treatments which are highly
cytotoxic to normal cells. Focus has been on T cells but natural killer (NK) cells have equal …