Thymoquinone and its therapeutic potentials

S Darakhshan, AB Pour, AH Colagar… - Pharmacological …, 2015 - Elsevier
Herbal medicine has attracted great attention in the recent years and is increasingly used as
alternatives to chemical drugs. Several lines of evidence support the positive impact of …

Therapeutic potential and pharmaceutical development of thymoquinone: a multitargeted molecule of natural origin

SN Goyal, CP Prajapati, PR Gore, CR Patil… - Frontiers in …, 2017 - frontiersin.org
Thymoquinone, a monoterpene molecule is chemically known as 2-methyl-5-isopropyl-1, 4-
benzoquinone. It is abundantly present in seeds of Nigella sativa L. that is popularly known …

[HTML][HTML] Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

YK Mahmoud, HMA Abdelrazek - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Recently, there is growing interest in the natural bioactive components having anticancer
activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa) …

Nano selenium ameliorates oxidative stress and inflammatory response associated with cypermethrin-induced neurotoxicity in rats

HFH Ali, NM El-Sayed, AAM Ahmed, PA Hanna… - Ecotoxicology and …, 2020 - Elsevier
Cypermethrin (CYP), a class II synthetic pyrethroid, is used to control household insects.
CYP can cross the blood-brain barrier to exert neurotoxicity through changes in sodium ion …

Therapeutic implications and clinical manifestations of thymoquinone

M Alam, GM Hasan, MM Ansari, R Sharma, DK Yadav… - Phytochemistry, 2022 - Elsevier
Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has
been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and …

Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats

S Ince, I Kucukkurt, HH Demirel, DA Acaroz, E Akbel… - Chemosphere, 2014 - Elsevier
The aim of the present study was to evaluate the possible protective effect of boron (B) on
cyclophosphamide (CYC) induced oxidative stress in rats. Totally, thirty Wistar albino male …

Antioxidant and cytoprotective effects of Nigellasativa L. seeds on the testis of monosodium glutamate challenged rats

M Abd-Elkareem, MAM Abd El-Rahman, NSA Khalil… - Scientific reports, 2021 - nature.com
Monosodium glutamate (MSG) is one of the most widely spread food additives that might
cause male infertility. However, Nigella sativa L. seeds (NSS) could provide a solution. This …

Protective effects of thymoquinone and diallyl sulphide against malathion-induced toxicity in rats

MM Abdel-Daim, AI Abushouk, SG Bungău… - … Science and Pollution …, 2020 - Springer
Malathion is a potent organophosphate insecticide that inhibits acetylcholinesterase (AChE)
enzyme. Our experimental objective was to investigate the beneficial effects of diallyl …

Thymoquinone and diallyl sulfide protect against fipronil-induced oxidative injury in rats

MM Abdel-Daim, HM Shaheen, AI Abushouk… - … Science and Pollution …, 2018 - Springer
Fipronil (FPN) is a phenylpyrazole insecticide, widely used for agricultural and veterinary
activities. Early reports indicated that FIP organ toxicity is primarily mediated by the induction …

Potential contribution of insecticide exposure and development of obesity and type 2 diabetes

X Xiao, JM Clark, Y Park - Food and chemical toxicology, 2017 - Elsevier
The introduction of insecticides has greatly improved agricultural productivity and human
nutrition; however, the wide use of insecticides has also sparked growing concern over their …