Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

Cell-type-specific gene expression is physiologically modulated by the binding of
transcription factors to genomic enhancer sequences, to which chromatin modifiers such as …

Ferroptosis is an outcome of metabolic disorders and closely linked to liver cancer.
However, the mechanism underlying the fine regulation of ferroptosis in liver cancer remains …

Background The gut microbiome, a key constituent of the colonic environment, has been
implicated as an important modulator of human health. The eukaryotic epigenome is …

All biological processes, living organisms, and ecosystems have evolved with the Sun that
confers a 24-hour periodicity to life on Earth. Circadian rhythms arose from evolutionary …

Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear
receptor family whose expression and activities are restricted to a limited number of organs …

Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of liver-specific gene
expression with potent tumor suppressor activity, yet many liver tumors express HNF4α. This …

HDAC3 is a specific and crucial member of the HDAC family. It is required for embryonic
growth, development, and physiological function. The regulation of oxidative stress is an …

Abstract Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling,
which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various …

Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by
cognitive decline and learning/memory impairment associated with neuronal cell loss …