Therapeutic potential of D-amino acid oxidase inhibitors for cognitive impairment associated with schizophrenia: learnings from luvadaxistat
RT Terry-Lorenzo, RH Fan, NA Khin… - International Journal of …, 2025 - academic.oup.com
Hypofunction of the N-methyl-D-aspartate receptor (NMDAR) has been proposed to underlie
the pathophysiology of schizophrenia, suggesting that promoting NMDAR activity may …
the pathophysiology of schizophrenia, suggesting that promoting NMDAR activity may …
Addressing brain metabolic connectivity in treatment-resistant schizophrenia: a novel graph theory-driven application of 18F-FDG-PET with antipsychotic dose …
G De Simone, F Iasevoli, A Barone, V Gaudieri… - Schizophrenia, 2024 - nature.com
Abstract Few studies using Positron Emission Tomography with 18F-fluorodeoxyglucose
(18F-FDG-PET) have examined the neurobiological basis of antipsychotic resistance in …
(18F-FDG-PET) have examined the neurobiological basis of antipsychotic resistance in …
Glutamate levels and symptom burden in high-risk and first-episode schizophrenia: a dual-voxel study of the anterior cingulate cortex
Background Reduced glutamatergic excitability of the anterior cingulate cortex (ACC) has
been long suspected in schizophrenia; recent observations support low glutamatergic tone …
been long suspected in schizophrenia; recent observations support low glutamatergic tone …
Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences
It is widely thought that the onset of psychotic symptoms in schizophrenia may arise from an
early neurotoxic phase, possibly related to oxidative stress or inflammation, and a late …
early neurotoxic phase, possibly related to oxidative stress or inflammation, and a late …
A multistage, dual voxel study of glutamate in the anterior cingulate cortex in schizophrenia supports a primary pyramidal dysfunction model of disorganization
Background: Schizophrenia is an illness where glutamatergic dysfunction in the anterior
cingulate cortex (ACC) has been long suspected; Recent in vivo evidence (Adams et al …
cingulate cortex (ACC) has been long suspected; Recent in vivo evidence (Adams et al …