The determination of intracellular drug concentrations can provide a better understanding of
the drug function and efficacy. Ideally, this should be performed nondestructively, with no …

Tremendous progress has been made in determining the structures of G-protein coupled
receptors (GPCR) and their complexes in recent years. However, understanding activation …

AMPs are short, mainly cationic membrane-active peptides found in all living organism. They
perform diverse roles including signaling and acting as a line of defense against bacterial …

Non-specific disruption of cellular membranes induced by aggregation of exogeneous β-
amyloid (Aβ) peptides is considered a viable pathological mechanism in Alzheimer's …

Antimicrobial peptides are an important class of membrane-active peptides that can provide
alternatives or complements to classic antibiotics. Among the many classes of AMPs, the …

With the sensitivity enhancements conferred by dynamic nuclear polarization (DNP), magic
angle spinning (MAS) solid state NMR spectroscopy experiments can attain the necessary …

Amyloid forms of α-synuclein adopt different conformations depending on environmental
conditions. Advances in structural biology have accelerated fibril characterization. However …

Abstract Dynamic Nuclear Polarization (DNP) is a technique that leverages the quantum
sensing capability of electron spins to enhance the sensitivity of nuclear magnetic …

The protein α-syn adopts a wide variety of conformations including an intrinsically
disordered monomeric form and an α-helical rich membrane-associated form that is thought …

Dynamic nuclear polarization (DNP) solid-state NMR enables detection of proteins at
endogenous concentrations in cells through sensitivity enhancement from nitroxide biradical …