The airway epithelium protects us from environmental insults, which we encounter with
every breath. Not only does it passively filter large particles, it also senses potential danger …

A number of mechanisms ensure that the intestine is protected from pathogens and also
against our own intestinal microbiota. The outermost of these is the secreted mucus, which …

Rationale: The respiratory tract constitutes an elaborate line of defense that is based on a
unique cellular ecosystem. Objectives: We aimed to investigate cell population distributions …

People worldwide are living longer, and it is estimated that by 2050, the proportion of the
world's population over 60 years of age will nearly double. Natural lung aging is associated …

Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by airway
remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA …

Type-2-cell-mediated immunity, rich in eosinophils, basophils, mast cells, CD4+ T helper 2
(Th2) cells, and type 2 innate lymphoid cells (ILC2s), protects the host from helminth …

The respiratory epithelium is lined by mucus, a gel consisting of water, ions, proteins, and
macromolecules. The major macromolecular components of mucus are the mucin …

Asthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and
metaplasia result in changes in stored and secreted mucin and the production of a …

Goblet cells (GCs) are specialized epithelial cells that line multiple mucosal surfaces and
have a well-appreciated role in barrier maintenance through the secretion of mucus …