Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …

Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor
vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical …

The therapeutic application of human induced pluripotent stem cells (hiPSCs) for cartilage
regeneration is largely hindered by the low yield of chondrocytes accompanied by …

Cartilage injury is extremely common and leads to joint dysfunction. Existing joint prostheses
do not remodel with host joint tissue. However, developing large-scale biomimetic …

Articular cartilage is a non-vascularized and poorly cellularized connective tissue that is
frequently damaged as a result of trauma and degenerative joint diseases such as …

Hyaline articular cartilage lacks blood vessels, lymphatics, and nerves and is characterised
by limited self‐repair ability following injury. Traditional techniques of articular cartilage …

Articular cartilage injury is a frequent worldwide disease, while effective treatment is urgently
needed. Due to lack of blood vessels and nerves, the ability of cartilage to self-repair is …

Chondrocytes and osteoblasts differentiated from induced pluripotent stem cells (iPSCs) will
provide insights into skeletal development and genetic skeletal disorders and will generate …

Background Bones have a remarkable capacity to heal upon fracture. Yet, in large defects or
compromised conditions healing processes become impaired, resulting in delayed or non …

Articular cartilage is a highly specialized tissue whose remarkable properties of
deformability, resistance to mechanical loading, and low-friction gliding are essential to joint …