The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …

The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

Amyloid proteins, which are considered 'villains' in many neurodegenerative diseases, form
enigmatic pathological strains that underlie disease pathogenesis and progression. Recent …

Amyloid-β (Aβ) is present in humans as a 39-to 42-amino acid residue metabolic product of
the amyloid precursor protein. Although the two predominant forms, Aβ (1–40) and Aβ (1 …

Liquid–liquid phase separation (LLPS) of proteins underlies the formation of membrane-less
organelles. While it has been recognized for some time that these organelles are of key …

The aggregation of proteins into structures known as amyloids is observed in many
neurodegenerative diseases, including Alzheimer's disease. Amyloids are composed of …

Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

In vitro, β-amyloid (Aβ) peptides form polymorphic fibrils, with molecular structures that
depend on growth conditions, plus various oligomeric and protofibrillar aggregates. Here …

Protein folding involves a large number of steps and conformations in which the folding
protein samples different thermodynamic states characterized by local minima. Kinetically …

Amyloid fibers and oligomers are associated with a great variety of human diseases
including Alzheimer's disease and the prion conditions. Here we attempt to connect recent …