The DNA-dependent protein kinase (DNA-PK) is a pivotal component of the DNA repair
machinery that governs the response to DNA damage, serving to maintain genome integrity …

The Ku protein-DNA-dependent protein kinase system is one of the major pathways by
which cells of higher eukaryotes respond to double-strand DNA breaks. The components of …

Glucocorticoids (GCs) have been widely used for decades as a first-line treatment for
inflammatory and autoimmune diseases. However, their use is often hampered by the onset …

Glucocorticoids (GCs) are hormones naturally released when the body perceives stress and
function to return homeostatic balance within various tissues. Synthetic GCs are widely …

Telomeres are specialized DNA/protein complexes that comprise the ends of eukaryotic
chromosomes. The highly expressed Ku heterodimer, composed of 70 and 80 K d subunits …

Glucocorticoid receptor (GR) cycles between a free liganded form that is localized to the
nucleus and a heat shock protein (hsp)-immunophilin-complexed, unliganded form that is …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase
that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression …

mRNAs that contain premature stop codons are selectively degraded in all eukaryotes
tested, a phenomenon termed “nonsense-mediated mRNA decay”(NMD) or “mRNA …

Negative regulation of neuronal serotonin (5-HT1A) receptor levels by glucocorticoids in
vivo may contribute to depression. Both types I (mineralocorticoid) and II (glucocorticoid) …

Ku is a heterodimeric protein composed of∼ 70-and∼ 80-kDa subunits (Ku70 and Ku80)
originally identified as an autoantigen recognized by the sera of patients with autoimmune …