The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol
management and cardiovascular health. Thirty years of research have uncovered supportive …

Cholesterol, the bulk end-product of the mevalonate pathway, is a key component of cellular
membranes and lipoproteins that transport lipids throughout the body. It is also a precursor …

This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against
colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 …

High-risk neuroblastoma exhibits transcriptional activation of the mevalonate pathway that
produces cholesterol and nonsterol isoprenoids. A better understanding of how this …

RAS-driven colorectal cancer relies on glucose metabolism to support uncontrolled growth.
However, monotherapy with glycolysis inhibitors like 2-deoxy-D-glucose causes limited …

Hepatocellular carcinoma (HCC) is a frequent primary aggressive cancer, a crucial cause of
cancer-related mortality globally. Simvastatin is a well-known safe cholesterol-lowering …

Down syndrome (DS) is the most common genetic cause of intellectual disability.
Mechanistically, oxidative stress and mitochondrial dysfunction are reported to be etiological …

Simple Summary Statins are medicines used to treat patients with high lipid levels
(hyperlipidemia). Studies have reported that patients undergoing statin therapy are at …

Chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnea (OSA), is
associated with various cardiovascular diseases. In the present study, we assessed the …

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with
limited therapeutic options available. We have recently demonstrated that lovastatin, a 3 …