Age-related macular degeneration (AMD) is a multifactorial disease influenced by a
combination of environmental factors and genetic variants. Genomic studies have been …

Age-related macular degeneration (AMD) is a progressive retinal disease and the major
cause of irreversible vision loss in the elderly. Numerous studies have found both common …

Considerable advances have been made in our understanding of age-related macular
degeneration (AMD) genetics over the past decade. The genetic associations discovered to …

Purpose: Rare genetic variants in complement factor I (CFI) that cause low systemic levels of
the protein (FI) have been reported as a strong risk factor for advanced age-related macular …

Factor I (FI) is one of the main inhibitors of complement activity, and numerous rare coding
variants have been reported in patients with age-related macular degeneration, atypical …

Introduction: Root dentin formation is an important process in tooth development. We tried to
identify potential genes that regulate root dentin formation which could be potentially used …

Genome-wide association studies (GWAS) have identified 52 independent variants at 34
genetic loci that are associated with age-related macular degeneration (AMD), the most …

Cancer‑associated fibroblasts (CAFs) are known to be essential in cancer initiation and
development. However, the role of CAFs in promoting ovarian cancer (OC) invasion remains …

Complement factor I (FI) is the nexus for classical, lectin and alternative pathway
complement regulation. FI is an 88kDa plasma protein that circulates in an inactive …

To expedite gene discovery in eye development and its associated defects, we previously
developed a bioinformatics resource-tool iSyTE (integrated Systems Tool for Eye gene …