[HTML][HTML] The complex biology of aryl hydrocarbon receptor activation in cancer and beyond

CA Opitz, P Holfelder, MT Prentzell, S Trump - Biochemical Pharmacology, 2023 - Elsevier
The aryl hydrocarbon receptor (AHR) signaling pathway is a complex regulatory network
that plays a critical role in various biological processes, including cellular metabolism …

Emerging role of m6A RNA methylation in nutritional physiology and metabolism

J Wu, K Frazier, J Zhang, Z Gan, T Wang… - Obesity …, 2020 - Wiley Online Library
Summary N6‐methyladenine (m6A) is the most prevalent type of internal RNA methylation in
eukaryotic mRNA and plays critical roles in regulating gene expression for fundamental …

The tryptophan derivative 6-formylindolo[3,2-b]carbazole, FICZ, a dynamic mediator of endogenous aryl hydrocarbon receptor signaling, balances cell growth and …

A Rannug, U Rannug - Critical reviews in toxicology, 2018 - Taylor & Francis
The aryl hydrocarbon receptor (AHR) is not essential to survival, but does act as a key
regulator of many normal physiological events. The role of this receptor in toxicological …

Targeting AhR as a novel therapeutic modality against inflammatory diseases

AS Cannon, PS Nagarkatti, M Nagarkatti - International Journal of …, 2021 - mdpi.com
For decades, activation of Aryl Hydrocarbon Receptor (AhR) was excluded from
consideration as a therapeutic approach due to the potential toxic effects of AhR ligands and …

The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value

ÁC Roman, JM Carvajal-Gonzalez, JM Merino… - Pharmacology & …, 2018 - Elsevier
The aryl hydrocarbon receptor (AhR) is well-known for its major contributions to the cellular
responses against environmental toxins and carcinogens. Notably, AhR has also emerged …

Redox signaling, mitochondrial metabolism, epigenetics and redox active phytochemicals

R Wu, S Li, R Hudlikar, L Wang, A Shannar… - Free Radical Biology …, 2022 - Elsevier
Biological redox signaling plays an important role in many diseases. Redox signaling
involves reductive and oxidative mechanisms. Oxidative stress occurs when reductive …

Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor

Z Xue, D Li, W Yu, Q Zhang, X Hou, Y He, X Kou - Food & function, 2017 - pubs.rsc.org
The aryl hydrocarbon receptor (AhR) is a pleiotropic nuclear factor that was originally
recognized as a “master” of xenobiotic metabolism but demonstrated recently to be a vital …

[HTML][HTML] Epigenetic regulation of cancer stem cells by the aryl hydrocarbon receptor pathway

S Akhtar, S Hourani, L Therachiyil, A Al-Dhfyan… - Seminars in cancer …, 2022 - Elsevier
Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells
generally referred as cancer stem cells (CSCs) that have been proposed as a strong …

Dysfunctional immune regulation in autoimmune hepatitis: from pathogenesis to novel therapies

M Vuerich, N Wang, A Kalbasi, JJ Graham… - Frontiers in …, 2021 - frontiersin.org
Autoimmune hepatitis (AIH) is a chronic inflammatory disorder characterized by
hypergammaglobulinemia, presence of serum autoantibodies and histological features of …

[HTML][HTML] A more holistic perspective of Alzheimer's disease: roles of gut microbiome, adipocytes, HPA axis, melatonergic pathway and astrocyte mitochondria in the …

G Anderson - Frontiers in Bioscience-Landmark, 2023 - imrpress.com
Alzheimer's disease is widely regarded as poorly treated due to poor conceptualization. For
40 years, Alzheimer's disease pathophysiology has focused on two culprits, amyloid-β …