Alzheimer's disease (AD) is an age-related dementia and neurodegenerative disorder,
characterized by Aβ and tau protein deposition impairing learning, memory and suppressing …

Astrocytes regulate synaptic communication and are essential for proper brain functioning.
In Alzheimer's disease (AD) astrocytes become reactive, which is characterized by an …

The imbalance between glutamate and γ‐aminobutyric acid (GABA) results in the loss of
synaptic strength leading to neurodegeneration. The dogma on the field considered neurons …

Neurodegenerative disorders are characterized by excitotoxicity and neuroinflammation that
finally lead to slow neuronal degeneration and death. Although neurons are the principal …

In Alzheimer's disease (AD), astrocyte properties are modified but their involvement in this
pathology is only beginning to be appreciated. The expression of connexins, proteins …

Neurodegenerative diseases are growing to become one of humanity's biggest health
problems, given the number of individuals affected by them. They cause enough mortalities …

In Alzheimer's disease (AD), one of the early responses to Aβ amyloidosis is recruitment of
microglia to areas of new plaque. Microglial receptors such as cannabinoid receptor 2 (CB2) …

Alzheimer's disease (AD) affects almost 35 million people worldwide. One of the
neuropathological features of AD is the presence of extracellular amyloid plaques, which are …

Metabotropic glutamate (mGlu) receptor ligands are under clinical development for the
treatment of CNS disorders with high social and economic burden, such as schizophrenia …

Glutamate is a major excitatory neurotransmitter in the central nervous system (CNS) and
abnormalities in the glutamatergic system underlie various CNS disorders. As metabotropic …