Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …

Iron is essential for several vital biological processes. Its deficiency or overload drives to the
development of several pathologies. To maintain iron homeostasis, the organism controls …

The hemochromatosis gene HFE was discovered in 1996, more than a century after clinical
and pathologic manifestations of hemochromatosis were reported. Linked to the major …

Little is known about the processes that enable influenza A viruses to jump into new host
species. Here we show that the non-structural protein1 nucleotide substitution, A374G …

Introduction Since its discovery, the hemochromatosis protein HFE has been primarily
defined by its role in iron metabolism and homeostasis, and its involvement in the genetic …

Iron homeostasis is essential for maintaining metabolic health and iron disorder has been
linked to chronic metabolic diseases. Increasing thermogenic capacity in adipose tissue has …

Many species of chiton are known to deposit magnetite (Fe3O4) within the cusps of their
heavily mineralized and ultrahard radular teeth. Recently, much attention has been paid to …

Nonsense-mediated decay (NMD) is an mRNA surveillance pathway that selectively
recognizes and degrades defective mRNAs carrying premature translation-termination …

Hepcidin is a main regulator of iron metabolism, of which abnormal expression affects
intestinal absorption and reticuloendothelial sequestration of iron by interacting with …

Hereditary hemochromatosis (HH) is a common autosomal recessive disorder of iron
overload among Caucasians of northern European descent. Over 85% of all cases with HH …