Chemometrics in metabolomics—a review in human disease diagnosis

R Madsen, T Lundstedt, J Trygg - Analytica chimica acta, 2010 - Elsevier
Metabolomics is a post genomic research field concerned with developing methods for
analysis of low molecular weight compounds in biological systems, such as cells, organs or …

Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery

Y Ni, G Xie, W Jia - Journal of proteome research, 2014 - ACS Publications
Colorectal cancer (CRC) is one of the most common cancers in the world, having both high
prevalence and mortality. It is usually diagnosed at advanced stages due to the limitations of …

MSClust: a tool for unsupervised mass spectra extraction of chromatography-mass spectrometry ion-wise aligned data

YM Tikunov, S Laptenok, RD Hall, A Bovy… - Metabolomics, 2012 - Springer
Mass peak alignment (ion-wise alignment) has recently become a popular method for
unsupervised data analysis in untargeted metabolic profiling. Here we present MSClust—a …

Distinct urinary metabolic profile of human colorectal cancer

Y Cheng, G Xie, T Chen, Y Qiu, X Zou… - Journal of proteome …, 2012 - ACS Publications
A full spectrum of metabolic aberrations that are directly linked to colorectal cancer (CRC) at
early curable stages is critical for developing and deploying molecular diagnostic and …

Review of mass spectrometry–based metabolomics in cancer research

DB Liesenfeld, N Habermann, RW Owen… - … , biomarkers & prevention, 2013 - AACR
Metabolomics, the systematic investigation of all metabolites present within a biologic
system, is used in biomarker development for many human diseases, including cancer. In …

Analytical protocols based on LC–MS, GC–MS and CE–MS for nontargeted metabolomics of biological tissues

S Naz, DC Moreira dos Santos, A García, C Barbas - Bioanalysis, 2014 - Taylor & Francis
Invasive, site-specific metabolite information could be better obtained from tissues. Hence,
highly sensitive mass spectrometry-based metabolomics coupled with separation …

Applications of mass spectrometry to metabolomics and metabonomics: Detection of biomarkers of aging and of age‐related diseases

RJ Mishur, SL Rea - Mass spectrometry reviews, 2012 - Wiley Online Library
Every 5 years or so new technologies, or new combinations of old ones, seemingly burst
onto the science scene and are then sought after until they reach the point of becoming …

Metabolomic investigation of gastric cancer tissue using gas chromatography/mass spectrometry

H Wu, R Xue, Z Tang, C Deng, T Liu, H Zeng… - Analytical and …, 2010 - Springer
Gastric cancer screening or diagnosis is mainly based on endoscopy and biopsy. The aim of
this study was to identify the difference of metabolomic profile between normal and …

Systematic review: contribution of the gut microbiome to the volatile metabolic fingerprint of colorectal neoplasia

R van Vorstenbosch, HR Cheng, D Jonkers, J Penders… - Metabolites, 2022 - mdpi.com
Colorectal cancer (CRC) has been associated with changes in volatile metabolic profiles in
several human biological matrices. This enables its non-invasive detection, but the origin of …

Development of a quantitative metabolomic approach to study clinical human fecal water metabolome based on trimethylsilylation derivatization and GC/MS analysis

X Gao, E Pujos-Guillot, JL Sebedio - Analytical chemistry, 2010 - ACS Publications
Metabolomic analysis of human fecal water recently aroused increasing attention with the
importance of fecal metabolome in exploring the relationships between symbiotic gut …