Elucidating the biology of yeast in its full complexity has major implications for science,
medicine and industry. One of the most critical processes determining yeast life and …

In the search for interventions against aging and age-related diseases, biological screening
platforms are indispensable tools to identify anti-aging compounds among large substance …

Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model
organisms and improve human health. The natural polyamine spermidine has been similarly …

Background Autophagy is the major intracellular degradation route in mammalian cells.
Systemic ablation of core autophagy-related (ATG) genes in mice leads to embryonic or …

Abstract Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during
Alzheimer's disease (AD). However, the etiology of its noxious cellular effects remains …

The metabolite α-ketoglutarate is membrane-impermeable, meaning that it is usually added
to cells in the form of esters such as dimethyl− ketoglutarate (DMKG), trifluoromethylbenzyl α …

Huntington's disease (HD) is a neurodegenerative disorder that leads to progressive
neuronal loss, provoking impaired motor control, cognitive decline, and dementia. So far, HD …

Molecular causes of aging and longevity interventions have witnessed an upsurge in the last
decade. The resurgent interests in the application of small molecules as potential …

The ubiquitin–proteasome system and the autophagy system are the two primary
mechanisms used by eukaryotes to maintain protein homeostasis, and both are closely …

The dynamic nature of the actin cytoskeleton is required to coordinate many cellular
processes, and a loss of its plasticity has been linked to accelerated cell aging and …