Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

Genome-wide association studies (GWASs) have identified thousands of loci associated
with hundreds of complex diseases and traits, and progress is being made toward …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …

Genome-wide association studies (GWAS) have identified thousands of variants associated
with complex traits, but their biological interpretation often remains unclear. Most of these …

Although genome-wide association studies have successfully identified thousands of risk
loci for complex traits, only a handful of the biologically causal variants, responsible for …

Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation
represent substantial challenges to elucidating mechanisms of trait-associated genetic …

We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

DNA-methylation (DNAm) levels at age-associated CpG sites can be combined into
epigenetic aging signatures to estimate donor age. It has been demonstrated that the …