Mitochondrial dysfunction has gained recognition as a contributing factor in many diseases.
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …

Diabetes mellitus affects the kidney in stages. At the onset of diabetes mellitus, in a subset of
diabetic patients the kidneys grow large, and glomerular filtration rate (GFR) becomes …

Diabetic nephropathy is a leading cause of end-stage renal disease. A better understanding
of the molecular mechanism involved in the early changes of the diabetic kidney may permit …

Diabetes mellitus contributes greatly to morbidity, mortality, and overall health care costs. In
major part, these outcomes derive from the high incidence of progressive kidney dysfunction …

Iodinated contrast media (ICM) induced acute kidney injury (AKI) accounts for 11% of cases
of AKI and is its third most common cause in hospitalized patients. However, the …

Experimental findings in vitro and in vivo illustrate enhanced hypoxia and the formation of
reactive oxygen species (ROS) within the kidney following the administration of iodinated …

NADPH oxidases have a distinct cellular localization in the kidney. Reactive oxygen species
(ROS) are produced in the kidney by fibroblasts, endothelial cells (EC), vascular smooth …

Renal Parenchymal Hypoxia, Hypoxia Adaptation, and the Patho... : Clinical Journal of the
American Society of Nephrology Renal Parenchymal Hypoxia, Hypoxia Adaptation, and the …

The kidney plays an essential role in blood pressure regulation by controlling short-term and
long-term NaCl and water balance. The thick ascending limb of the loop of Henle (TAL) …

Hypoxia of the kidney in diabetes could predispose it to develop acute and chronic renal
failure. To examine the relationship between renal hypoxia and renal failure, we measured …