Hepatic lipid metabolism is a series of complex processes that control influx and efflux of not
only hepatic lipid pools, but also organismal pools. Lipid homeostasis is usually tightly …

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with
significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and …

Heavy alcohol use is the cause of alcoholic liver disease (ALD). The ALD spectrum ranges
from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries …

Chronic alcohol consumption perturbs lipid metabolism as it increases adipose tissue
lipolysis and leads to ectopic fat deposition within the liver and the development of alcoholic …

Background: Obesity is a risk factor for metabolic diseases, while preadipocyte
differentiation or adipogenesis is closely related to obesity occurrence. Long noncoding …

Severe alcoholic hepatitis (SAH) is a deadly liver disease without an effective medical
therapy. Although SAH mortality is known to correlate with hepatic accumulation of immature …

Nuclear receptors are ligand-activated transcription factors that regulate gene expression of
a variety of key molecular signals involved in liver fibrosis. The primary cellular driver of liver …

Background & Aims Nonalcoholic steatohepatitis (NASH) is commonly observed in patients
with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for …

Primary tumors of the liver represent the fifth most common type of cancer in the world and
the third leading cause of cancer-related death. Case-control studies from different countries …

Background Previous research reported inconsistent findings regarding the effects of
conjugated linoleic acid (CLA) supplementation on liver enzymes. This systematic review …