Characterizing variability and uncertainty associated with transcriptomic dose–response modeling

JD Ewald, N Basu, D Crump… - … Science & Technology, 2022 - ACS Publications
Transcriptomics dose–response analysis (TDRA) has emerged as a promising approach for
integrating toxicogenomics data into a risk assessment context; however, variability and …

Hepatic transcriptomic responses to ethinylestradiol in two life stages of Japanese quail

YS Jeon, D Crump, E Boulanger… - Environmental …, 2022 - Wiley Online Library
Chemical risk assessment for avian species typically depends on information from toxicity
tests performed in adult birds. Early‐life stage (ELS) toxicity tests have been proposed as an …

Contaminants of Concern and Spatiotemporal Metabolomic Changes in Quagga Mussels (Dreissena bugensis rostriformis) from the Milwaukee Estuary (Wisconsin …

N Fuller, KL Kimbrough, E Davenport… - Environmental …, 2024 - Wiley Online Library
Environmental metabolomics has emerged as a promising technique in the field of
biomonitoring and as an indicator of aquatic ecosystem health. In the Milwaukee Estuary …

Development and initial testing of EcoToxChip, a novel toxicogenomics tool for environmental management and chemical risk assessment

D Crump, G Hickey, E Boulanger… - Environmental …, 2023 - Wiley Online Library
New approach methods (NAMs) are increasingly important to help accelerate the pace of
ecological risk assessment and offer more ethical, affordable, and efficient alternatives to …

Phenology of the transcriptome coincides with the physiology of double-crested cormorant embryonic development

SJ Wallace, SR de Solla, VS Langlois - Comparative Biochemistry and …, 2022 - Elsevier
The rigorous timing of the dynamic transcriptome within the embryo has to be well
orchestrated for normal development. Identifying the phenology of the transcriptome along …