A review of hot melt extrusion technology: advantages, applications, key factors and future prospects
X Li, X Hong, S Shuai, X Han, C Li, H Zhang… - Journal of Drug Delivery …, 2024 - Elsevier
After decades of development, hot melt extrusion (HME) technology has matured as a well-
established pharmaceutical methodology. Through the process of extruding both drug and …
established pharmaceutical methodology. Through the process of extruding both drug and …
Structural Features of the Glassy State and Their Impact on the Solid-State Properties of Organic Molecules in Pharmaceutical Systems
G Zografi, A Newman, E Shalaev - Journal of Pharmaceutical Sciences, 2024 - Elsevier
This paper reviews the structure and properties of amorphous active pharmaceutical
ingredients (APIs), including small molecules and proteins, in the glassy state (below the …
ingredients (APIs), including small molecules and proteins, in the glassy state (below the …
Crystallization and intermolecular hydrogen bonding in carbamazepine-polyvinyl pyrrolidone solid dispersions: An experiment and molecular simulation study on drug …
H Wang, Y Luan, M Li, S Wu, S Zhang, J Xue - International Journal of …, 2024 - Elsevier
The choice of drug content is a critical factor as far as the solid dispersion is concerned. This
investigation aims to build the relationship between the drug content, intermolecular …
investigation aims to build the relationship between the drug content, intermolecular …
High loading of lipophilic compounds in mesoporous silica for improved solubility and dissolution performance
Loading poorly soluble active pharmaceutical ingredients (API) into mesoporous silica can
enable API stabilization in non-crystalline form, which leads to improved dissolution. This is …
enable API stabilization in non-crystalline form, which leads to improved dissolution. This is …
High-Throughput Microarray Approaches for Predicting the Stability of Drug–Polymer Solid Dispersions
Amorphous solid dispersions (ASDs) offer a well-recognized strategy to improve the
effective solubility and, hence, bioavailability of poorly soluble drugs. In this study, we …
effective solubility and, hence, bioavailability of poorly soluble drugs. In this study, we …
Poly(vinylpyridine-co-vinylpyridine N-oxide) Excipients Mediate Rapid Dissolution and Sustained Supersaturation of Posaconazole Amorphous Solid Dispersions
The chemical structure of excipients molecularly mixed in an amorphous solid dispersion
(ASD) has a significant impact on properties of the ASD including dissolution behavior …
(ASD) has a significant impact on properties of the ASD including dissolution behavior …
Predicting Drug-Polymer Compatibility in Amorphous Solid Dispersions by MD Simulation: On the Trap of Solvation Free Energies
T Higginbotham, K Meier, J Ramírez… - Molecular …, 2024 - ACS Publications
Amorphous solid dispersions (ASDs) are a prevalent method for increasing the
bioavailability and apparent solubility of poorly soluble drugs. Consequently, extensive …
bioavailability and apparent solubility of poorly soluble drugs. Consequently, extensive …
Effects of hypromellose acetate succinate on recrystallization inhibition, miscibility, and dissolution enhancement of baloxavir marboxil solid dispersions
L Wang, H Wu, Z Wang, Z Ding, Y Zhao, S Li… - International Journal of …, 2024 - Elsevier
Solid dispersions (SDs) have emerged as a promising strategy to enhance the solubility and
bioavailability of poorly soluble active pharmaceutical ingredients. However, SDs tend to …
bioavailability of poorly soluble active pharmaceutical ingredients. However, SDs tend to …
Understanding the Influence of API Conformations on Amorphous Dispersion Formation Potential Predictions using the R3m Molecular Descriptor
The R 3 m molecular descriptor (R-GETAWAY third-order autocorrelation index weighted by
the atomic mass) has previously been shown to encode molecular attributes that appear to …
the atomic mass) has previously been shown to encode molecular attributes that appear to …
Investigating the Implications of Coexistent Halogen and Hydrogen Bonds on the Physical Stability of Amorphous Solid Dispersions Using Time–Temperature …
M Bookwala, J Shi, IS Buckner, S Bates… - Crystal Growth & …, 2024 - ACS Publications
Solution nuclear magnetic resonance spectroscopy was used to characterize the interaction
landscape between polyvinylpyrrolidone vinyl acetate copolymer (PVPVA) and each of the …
landscape between polyvinylpyrrolidone vinyl acetate copolymer (PVPVA) and each of the …