The oxygen paradox tells us that oxygen is both necessary for aerobic life and toxic to all life
forms. Reactive oxygen species (ROS) touch every biological and medical discipline …

A growing body of epidemiologic and experimental data point to chronic bacterial and viral
infections as possible risk factors for neurodegenerative diseases, including Alzheimer's …

Astrocytes, the most abundant glial cell types in the brain, provide metabolic and trophic
support to neurons and modulate synaptic activity. Accordingly, impairment in these …

The list of pathophysiological conditions associated with the overproduction of superoxide
expands every day. Much of the knowledge compiled on the role of this radical in disease …

Astrocytes are the most numerous cell type in the brain, and their physiological roles are
essential for normal brain function. Studies of post-mortem brain tissue samples from …

Cells of macrophage lineage represent a key target of human immunodeficiency virus (HIV)
in addition to CD4-lymphocytes. The absolute number of infected macrophages in the body …

In humans, several pathologies involve the overproduction of reactive oxygen species. Metal-
containing catalytic antioxidants have emerged as a novel class of potential therapeutic …

Importance of the field: CF airway mucus can be infected by opportunistic microorganisms,
notably Pseudomonas aeruginosa. Once organisms are established as biofilms, even the …

Apoptosis, or programmed cell death, is a key event in biologic homeostasis but is also
involved in the pathogenesis of many human diseases including human immunodeficiency …

The deaths of neurons, astrocytes and endothelial cells have been described in patients
with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead …