Highlights•PBPK modeling bridges drug properties and PK behaviours in drug discovery
and development.•The PBPK is often used in oral formulation development, to address …

Background: The incorporation of genomic testing into clinical practice constitutes an
opportunity to improve patients' lives, as it makes possible the implementation of innovative …

MicroRNAs (miRNAs) create systems networks and gene-expression circuits through
molecular signaling and cell interactions that contribute to health imbalance and the …

Our study aims to develop a data-driven framework utilizing heterogenous electronic
medical and clinical records and advanced Machine Learning (ML) approaches for:(i) the …

Exosome selectivity mechanisms underlying exosome–target cell interactions and the
specific traits affecting their capability to communicate still remain unclear. Moreover, the …

In contemporary healthcare, integrating bioinformatics with physiotherapy and nursing
science has emerged as a promising approach to personalized patient care and clinical …

Innovative tumor profiling methodologies are utilized to elucidate the pharmacogenomic
landscape of tumor cells in order to support the molecularly guided delivery of therapeutics …

This retrospective study evaluates the link between an adverse drug reaction (ADR) or a non-
response to treatment and cytochromes P450 (CYP), P-glycoprotein (P-gp) or catechol-O …

Every scientific biomedical sector is now witnessing rapidly increasing computing power
capacity, thus allowing the simulation and modeling of complex biological processes …

CRISSPAC is an open-source web-based platform for the prediction of the Syntax Score and
the severity of coronary artery disease (CAD) providing a variety of data analytics and …