The evolutionary ecology of transmissible cancers

B Ujvari, RA Gatenby, F Thomas - Infection, Genetics and Evolution, 2016 - Elsevier
Transmissible tumours, while rare, present a fascinating opportunity to examine the
evolutionary dynamics of cancer as both an infectious agent and an exotic, invasive species …

[HTML][HTML] Rapid evolutionary response to a transmissible cancer in Tasmanian devils

B Epstein, M Jones, R Hamede, S Hendricks… - Nature …, 2016 - nature.com
Although cancer rarely acts as an infectious disease, a recently emerged transmissible
cancer in Tasmanian devils (Sarcophilus harrisii) is virtually 100% fatal. Devil facial tumour …

A second transmissible cancer in Tasmanian devils

RJ Pye, D Pemberton, C Tovar… - Proceedings of the …, 2016 - National Acad Sciences
Clonally transmissible cancers are somatic cell lineages that are spread between
individuals via the transfer of living cancer cells. There are only three known naturally …

Immunology of naturally transmissible tumours

HV Siddle, J Kaufman - Immunology, 2015 - Wiley Online Library
Naturally transmissible tumours can emerge when a tumour cell gains the ability to pass as
an infectious allograft between individuals. The ability of these tumours to colonize a new …

Density trends and demographic signals uncover the long‐term impact of transmissible cancer in Tasmanian devils

BT Lazenby, MW Tobler, WE Brown… - Journal of Applied …, 2018 - Wiley Online Library
Monitoring the response of wild mammal populations to threatening processes is
fundamental to effective conservation management. This is especially true for infectious …

Biting injuries and transmission of T asmanian devil facial tumour disease

RK Hamede, H McCallum… - Journal of Animal Ecology, 2013 - Wiley Online Library
The T asmanian devil is threatened with extinction by devil facial tumour disease (DFTD), a
unique infectious cancer in which the tumour cells themselves, which derive from a single …

The ecology and evolution of wildlife cancers: Applications for management and conservation

R Hamede, R Owen, H Siddle, S Peck… - Evolutionary …, 2020 - Wiley Online Library
Ecological and evolutionary concepts have been widely adopted to understand host–
pathogen dynamics, and more recently, integrated into wildlife disease management …

Conserving adaptive potential: lessons from Tasmanian devils and their transmissible cancer

PA Hohenlohe, HI McCallum, ME Jones… - Conservation …, 2019 - Springer
Maintenance of adaptive genetic variation has long been a goal of management of natural
populations, but only recently have genomic tools allowed identification of specific loci …

Restoring faith in conservation action: Maintaining wild genetic diversity through the Tasmanian devil insurance program

KA Farquharson, EA McLennan, Y Cheng, L Alexander… - Iscience, 2022 - cell.com
Conservation breeding programs aim to maintain 90% wild genetic diversity, but rarely
assess functional diversity. Here, we compare both genome-wide and functional diversity (in …

Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils

YM Kwon, K Gori, N Park, N Potts, K Swift, J Wang… - PLoS …, 2020 - journals.plos.org
Devil facial tumour 1 (DFT1) is a transmissible cancer clone endangering the Tasmanian
devil. The expansion of DFT1 across Tasmania has been documented, but little is known of …