[HTML][HTML] Hematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands
M Kasbekar, CA Mitchell, MA Proven, E Passegué - Cell Stem Cell, 2023 - cell.com
Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …
transition through a series of functional states characterized by expansion during fetal …
TET Enzymes in the Immune system: from DNA demethylation to immunotherapy, inflammation, and cancer
IF López-Moyado, M Ko, PG Hogan… - Annual Review of …, 2024 - annualreviews.org
Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …
Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis
Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In
this study, we establish that aging of the immune system, regardless of the age of the stroma …
this study, we establish that aging of the immune system, regardless of the age of the stroma …
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging
Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations,
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …
Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells
Clonal hematopoiesis (CH) is defined as a single hematopoietic stem/progenitor cell
(HSPC) gaining selective advantage over a broader range of HSPCs. When linked to …
(HSPC) gaining selective advantage over a broader range of HSPCs. When linked to …
Hematopoietic stem cells and the immune system in development and aging
D Shevyrev, V Tereshchenko, TN Berezina… - International Journal of …, 2023 - mdpi.com
Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …
whole variety of cells of the immune system. Developing in the early embryo, passing …
Clonal hematopoiesis and hematological malignancy
WG Dunn, MA McLoughlin, GS Vassiliou - The Journal of Clinical …, 2024 - jci.org
Clonal hematopoiesis (CH), the expansion of hematopoietic stem cells and their progeny
driven by somatic mutations in leukemia-associated genes, is a common phenomenon that …
driven by somatic mutations in leukemia-associated genes, is a common phenomenon that …
The role of inflammation in the initiation and progression of myeloid neoplasms
Myeloid malignancies are devastating hematologic cancers with limited therapeutic options.
Inflammation is emerging as a novel driver of myeloid malignancy, with important …
Inflammation is emerging as a novel driver of myeloid malignancy, with important …
Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis
Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related
diseases, including hematologic malignancy and atherosclerotic cardiovascular disease …
diseases, including hematologic malignancy and atherosclerotic cardiovascular disease …
Biomarkers of aging
Aging Biomarker Consortium, H Bao, J Cao… - Science China Life …, 2023 - Springer
Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …