Low-intensity ultrasound neuromodulation: an overview of mechanisms and emerging human applications
Background There is an emerging need for noninvasive neuromodulation techniques to
improve patient outcomes while minimizing adverse events and morbidity. Low-intensity …
improve patient outcomes while minimizing adverse events and morbidity. Low-intensity …
Transcranial focused ultrasound (tFUS) and transcranial unfocused ultrasound (tUS) neuromodulation: from theoretical principles to stimulation practices
Transcranial focused ultrasound is an emerging technique for non-invasive
neurostimulation. Compared to magnetic or electric non-invasive brain stimulation, this …
neurostimulation. Compared to magnetic or electric non-invasive brain stimulation, this …
Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation
The causal role of an area within a neural network can be determined by interfering with its
activity and measuring the impact. Many current reversible manipulation techniques have …
activity and measuring the impact. Many current reversible manipulation techniques have …
The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation
J Zhu, Q Xian, X Hou, KF Wong, T Zhu… - Proceedings of the …, 2023 - National Acad Sciences
Transcranial low-intensity ultrasound is a promising neuromodulation modality, with the
advantages of noninvasiveness, deep penetration, and high spatiotemporal accuracy …
advantages of noninvasiveness, deep penetration, and high spatiotemporal accuracy …
Offline impact of transcranial focused ultrasound on cortical activation in primates
To understand brain circuits it is necessary both to record and manipulate their activity.
Transcranial ultrasound stimulation (TUS) is a promising non-invasive brain stimulation …
Transcranial ultrasound stimulation (TUS) is a promising non-invasive brain stimulation …
Transcranial pulse stimulation with ultrasound in Alzheimer's disease—a new navigated focal brain therapy
R Beisteiner, E Matt, C Fan, H Baldysiak… - Advanced …, 2020 - Wiley Online Library
Ultrasound‐based brain stimulation techniques may become a powerful new technique to
modulate the human brain in a focal and targeted manner. However, for clinical brain …
modulate the human brain in a focal and targeted manner. However, for clinical brain …
The mechanosensitive ion channel Piezo1 significantly mediates in vitro ultrasonic stimulation of neurons
Ultrasound brain stimulation is a promising modality for probing brain function and treating
brain disease non-invasively and with high spatiotemporal resolution. However, the …
brain disease non-invasively and with high spatiotemporal resolution. However, the …
Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel PIEZO2
BU Hoffman, Y Baba, SA Lee… - Proceedings of the …, 2022 - National Acad Sciences
Neurons of the peripheral nervous system (PNS) are tasked with diverse roles, from
encoding touch, pain, and itch to interoceptive control of inflammation and organ physiology …
encoding touch, pain, and itch to interoceptive control of inflammation and organ physiology …
Photoacoustic carbon nanotubes embedded silk scaffolds for neural stimulation and regeneration
Neural interfaces using biocompatible scaffolds provide crucial properties, such as cell
adhesion, structural support, and mass transport, for the functional repair of nerve injuries …
adhesion, structural support, and mass transport, for the functional repair of nerve injuries …
A clinical system for non-invasive blood–brain barrier opening using a neuronavigation-guided single-element focused ultrasound transducer
Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is currently being
investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic …
investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic …