Towards a synthetic cell cycle

L Olivi, M Berger, RNP Creyghton… - Nature …, 2021 - nature.com
Recent developments in synthetic biology may bring the bottom-up generation of a synthetic
cell within reach. A key feature of a living synthetic cell is a functional cell cycle, in which …

Structural insights into the mechanism of dynamin superfamily proteins

JR Jimah, JE Hinshaw - Trends in Cell Biology, 2019 - cell.com
Dynamin superfamily proteins (DSPs) mediate membrane fission and fusion necessary for
endocytosis, organelle biogenesis and maintenance, as well as for bacterial cytokinesis …

SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system

N Pende, A Sogues, D Megrian, A Sartori-Rupp… - Nature …, 2021 - nature.com
Most archaea divide by binary fission using an FtsZ-based system similar to that of bacteria,
but they lack many of the divisome components described in model bacterial organisms …

c-di-GMP arms an anti-σ to control progression of multicellular differentiation in Streptomyces

KA Gallagher, MA Schumacher, MJ Bush, MJ Bibb… - Molecular Cell, 2020 - cell.com
Streptomyces are our primary source of antibiotics, produced concomitantly with the
transition from vegetative growth to sporulation in a complex developmental life cycle. We …

Structural, metabolic and evolutionary comparison of bacterial endospore and exospore formation

P Beskrovnaya, DL Sexton… - Frontiers in …, 2021 - frontiersin.org
Sporulation is a specialized developmental program employed by a diverse set of bacteria
which culminates in the formation of dormant cells displaying increased resilience to …

Synthetic membrane shaper for controlled liposome deformation

N De Franceschi, W Pezeshkian, A Fragasso… - ACS …, 2022 - ACS Publications
Shape defines the structure and function of cellular membranes. In cell division, the cell
membrane deforms into a “dumbbell” shape, while organelles such as the autophagosome …

Dynamin A as a one-component division machinery for synthetic cells

N De Franceschi, R Barth, S Meindlhumer… - Nature …, 2024 - nature.com
Membrane abscission, the final cut of the last connection between emerging daughter cells,
is an indispensable event in the last stage of cell division and in other cellular processes …

Bacteriostatic cells instead of bacteriostatic antibiotics?

F Baquero, J Rodríguez-Beltrán, BR Levin - Mbio, 2024 - Am Soc Microbiol
This year we commemorate the centennial of the birth of the mature concept of
bacteriostasis by John W. Churchman at Cornell University Medical School. The term …

Mycobacterial dynamin-like protein IniA mediates membrane fission

M Wang, X Guo, X Yang, B Zhang, J Ren, A Liu… - Nature …, 2019 - nature.com
Mycobacterium tuberculosis infection remains a major threat to human health worldwide.
Drug treatments against tuberculosis (TB) induce expression of several mycobacterial …

Cyanobacterial membrane dynamics in the light of eukaryotic principles

C Siebenaller, D Schneider - Bioscience Reports, 2023 - portlandpress.com
Intracellular compartmentalization is a hallmark of eukaryotic cells. Dynamic membrane
remodeling, involving membrane fission/fusion events, clearly is crucial for cell viability and …