Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

The lung is composed of airways and lung parenchyma, and the extracellular matrix (ECM)
contains the main building blocks of both components. The ECM provides physical support …

Biglycan, a small leucine-rich proteoglycan, is a ubiquitous ECM component; however, its
biological role has not been elucidated in detail. Here we show that biglycan acts in …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular
processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and …

Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a
broad binding repertoire that encompasses matrix structural components, such as collagens …

An emerging body of evidence indicates that secreted proteoglycans act as signaling
molecules, in addition to their canonical function in maintaining and regulating the …

Increased attention is paid to the structural components of tissues. These components are
mostly collagens and various proteoglycans. Emerging evidence suggests that altered …

Connective tissues within the synovial joints are characterized by their dense extracellular
matrix and sparse cellularity. With injury or disease, however, tissues commonly experience …

Research over the past few years has provided fascinating results indicating that biglycan,
besides being a ubiquitous structural component of the extracellular matrix (ECM), may act …