Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by …

SA Bernal-Chávez, A Romero-Montero… - Journal of Biological …, 2023 - Springer
The freeze-thaw (F/T) method is commonly employed during the processing and handling of
drug substances to enhance their chemical and physical stability and obtain pharmaceutical …

Green synthesis of PEG-coated MIL-100 (Fe) for controlled release of dacarbazine and its anticancer potential against human melanoma cells

M Barjasteh, M Vossoughi, M Bagherzadeh… - International Journal of …, 2022 - Elsevier
In this study, the potential of using MIL-100 (Fe) metal–organic framework (MOF) for loading
and controlling the release of dacarbazine (DTIC) was evaluated for in vitro treatment of …

Electrospun PVA-Dacarbazine nanofibers as a novel nano brain-implant for treatment of glioblastoma: in silico and in vitro characterization

L Steffens, AM Morás, PR Arantes, K Masterson… - European Journal of …, 2020 - Elsevier
Malignant glioblastoma (GB) treatment consists of resection surgery followed by
radiotherapy and chemotherapy (CT). Despite several implications, such as systemic toxicity …

Bottom-up strategy to forecast the drug location and release kinetics in antitumoral electrospun drug delivery systems

R Longo, M Raimondo, L Vertuccio… - International Journal of …, 2023 - mdpi.com
Electrospun systems are becoming promising devices usable for topical treatments. They
are eligible to deliver different therapies, from anti-inflammatory to antitumoral. In the current …

Characterization of gels and films produced from Pinhão seed coat nanocellulose as a potential use for wound healing dressings and screening of its compounds …

TAM de Lima, GG de Lima, BS Chee, JG Henn… - Polymers, 2022 - mdpi.com
The reuse of agro-industrial waste assumes great importance today. Pinhão is the seed of
Araucaria angustifolia, which is native to the mountains of southern Brazil, Paraguay, and …

Plantago australis Hydroethanolic Extract-Loaded Formulations: Promising Dressings for Wound Healing

LS Reinhardt, JG Henn, AM Moras… - Revista Brasileira de …, 2021 - Springer
The productions of wound dressings involve three key goals: wound protection, suitable
environment, and acceleration of the healing process. This study was based on our previous …

Development, characterization and cell viability inhibition of PVA spheres loaded with Doxorubicin and 4′-Amino-1-Naphthyl-Chalcone (D14) for osteosarcoma

V Seba, GG de Lima, BL Pereira, G Silva, LS Reinhardt… - Polymers, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are naturally occurring polyphenols with known
anticancer activity against a variety of tumor cell lines, including osteosarcoma (OS). In this …

Modified polysaccharides in wound healing

L Steffens, MCH de Barros Dias, PR Arantes… - Tailor-Made …, 2020 - Elsevier
The wound healing process involves a basic feature of the human body for repairing
damaged skin. Dressings have a significant role in the management of healing. Hence, it is …

Nanopolymeric systems to improve brain cancer treatment outcomes

L Steffens, MCH de Barros Dias, PR Arantes… - … and Challenges in …, 2021 - Elsevier
Brain tumors, especially glioblastomas, are an unsolved clinical problem and a challenge for
the current medical science given the limitations of conventional therapies. Brain physiology …

[引用][C] Sistemas poliméricos de entrega de substâncias: do aumento da eficácia do processo de cicatrização a aplicações oncológicas

LS Reinhardt - 2022 - repositorio.ufcspa.edu.br
Os sistemas de entrega de fármacos são uma área de estudo relativamente nova, mas em
rápido desenvolvimento, que descreve como materiais biocompatíveis são empregados …