Since their discovery 20 years ago, microRNAs have been related to posttranscriptional
regulation of gene expression in major cardiac physiological and pathological processes …

miR-21 is a 22-nucleotide long microRNA that matches target mRNAs in a complementary
base pairing fashion and regulates gene expression by repressing or degrading target …

Ventricular remodeling (VR) is a complex pathological process of cardiomyocyte apoptosis,
cardiac hypertrophy, and myocardial fibrosis, which is often caused by various …

Cardiovascular diseases (CVDs) represent a major global health problem, due to their
continued high incidences and mortality. The last few decades have witnessed new …

The extracellular matrix (ECM) creates a multifaceted system for the interaction of diverse
structural proteins, matricellular molecules, proteoglycans, hyaluronan, and various …

The microRNA-29 family members miR-29a-3p, miR-29b-3p, and miR-29c-3p are
ubiquitously expressed and consistently increased in various tissues and cell types in …

Myocardial fibrosis is observed in various cardiovascular diseases and plays a key role in
the impairment of cardiac function. Endomyocardial biopsy, as the gold standard for the …

MicroRNAs (miRNAs) are a class of non-coding RNAs of about 20 nucleotides in length,
involved in the regulation of many biochemical pathways in the human body. The level of …

Doxorubicin (DOX) is a highly effective chemotherapy agent that often causes cardiotoxicity.
Despite a number of extensive studies, the risk for DOX cardiotoxicity remains unpredictable …

Apoptosis and fibrosis play a vital role in myocardial infarction (MI) induced tissue injury.
Although microRNAs have been the focus of many studies on cardiac apoptosis and fibrosis …