[HTML][HTML] A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

YF Rego, MP Queiroz, TO Brito, PG Carvalho… - Journal of advanced …, 2018 - Elsevier
Ureases are enzymes that hydrolyze urea into ammonium and carbon dioxide. They have
received considerable attention due to their impacts on living organism health, since the …

Cyanoacetamide derivatives as synthons in heterocyclic synthesis

AA Fadda, S Bondock, R Rabie… - Turkish Journal of …, 2008 - journals.tubitak.gov.tr
This review presents a systematic and comprehensive survey of the methods of preparation
and the chemical reactivity of cyanoacetamide derivatives. These compounds are important …

Synthesis, single crystal, characterization and computational study of 2-amino-N-cyclopropyl-5-ethyl-thiophene-3-carboxamide

G Khanum, A Fatima, N Siddiqui, DD Agarwal… - Journal of Molecular …, 2022 - Elsevier
amino-N-cyclopropyl-5-ethylthiophene-3-carboxamide (ACPETC)(C 10 H 14 N 2 OS) has
been synthesized, characterized via single-crystal X-ray diffraction at 296 K and studied …

Cyanoacetamide MCR (III): Three-component Gewald reactions revisited

K Wang, D Kim, A Domling - Journal of combinatorial chemistry, 2010 - ACS Publications
Cyanoacetic acid derivatives are the starting materials for a plethora of multicomponent
reaction (MCR) scaffolds. Here we describe valuable general protocols for the synthesis of …

A facile and practical one-pot synthesis of multisubstituted 2-aminothiophenes via imidazole-catalyzed Gewald reaction

XG Huang, J Liu, J Ren, T Wang, W Chen, BB Zeng - Tetrahedron, 2011 - Elsevier
A simple and efficient procedure was developed for the synthesis of multisubstituted 2-
aminothiophene derivatives. In the presence of catalytic amount of imidazole, ketones or …

DBU-mediated [4+ 1] annulations of donor–acceptor cyclopropanes with carbon disulfide or thiourea for synthesis of 2-aminothiophene-3-carboxylates

Z Su, S Qian, S Xue, C Wang - Organic & Biomolecular Chemistry, 2017 - pubs.rsc.org
DBU-mediated [4+ 1] annulations of donor–acceptor cyclopropanes with carbon disulfide or
thiourea to form 2-aminothiophene-3-carboxylate derivatives have been discovered. This …

Thiophene syntheses by ring forming multicomponent reactions

K Schaper, TJJ Müller - Sulfur Chemistry, 2019 - Springer
Thiophenes occur as important building blocks in natural products, pharmaceutical active
compounds, and in materials for electronic and opto-electronic devices. Therefore, there is a …

An efficient one-pot synthesis of substituted 2-aminothiophenes via three-component Gewald reaction catalyzed by L-proline

T Wang, XG Huang, J Liu, B Li, JJ Wu, KX Chen… - Synlett, 2010 - thieme-connect.com
An efficient one-pot procedure for the direct catalytic synthesis of substituted 2-
aminothiophenes catalyzed by l-proline under mild reaction conditions has been developed …

Activation of Elemental Sulfur by Electrogenerated Cyanomethyl Anion: Synthesis of Substituted 2‐Aminothiophenes by the Gewald Reaction

M Feroci, I Chiarotto, L Rossi… - Advanced Synthesis & …, 2008 - Wiley Online Library
The activation of elemental sulfur (S8) has been achieved by means of electrogenerated
cyanomethyl anion [easily obtained by galvanostatic reduction from acetonitrile …

Bovine serum albumin-catalyzed one-pot synthesis of 2-aminothiophenes via Gewald reaction

DD Zhao, L Li, F Xu, Q Wu, XF Lin - Journal of Molecular Catalysis B …, 2013 - Elsevier
A novel bovine serum albumin (BSA)-catalyzed Gewald reaction in one-pot was developed
in this work. The influence of reaction conditions including solvent, temperature and catalyst …