Each year in the US,∼ 1.5 million people sustain a traumatic brain injury (TBI). Victims of TBI
can suffer from chronic post-TBI symptoms, such as sensory and motor deficits, cognitive …

Rodent models of depression have been developed in an effort to identify novel
antidepressant compounds and to further our understanding of the pathophysiology of …

Background: Accumulating evidence suggests that cannabidiol (CBD) may be an effective
and safe anxiolytic agent and potentially also an antidepressant. Aim: The objective of this …

A growing body of evidence from human postmortem and animal studies suggests that
deficits in glial cell (particularly astrocytes) density and function, in limbic regions of the brain …

Background While the etiology of depression is not clearly understood at the present time,
this mental disorder is thought be a complex and multifactorial trait with important genetic …

In the current study we explored behavioral and endocrinological effects of exposure to
social isolation during adulthood in two different genetic animal models of depression, the …

BACKGROUND: Availability of peripheral biomarkers for depression could aid diagnosis
and help to predict treatment response. The objective of this work was to analyse the …

The relationship between trait stress-sensitivity, avoidance acquisition and perseveration of
avoidance was examined using male Wistar–Kyoto (WKY) and Sprague–Dawley (SD) rats …

The purpose of the present study was to evaluate for the first time the stress-induced
hypothalamus–pituitary–adrenal (HPA), adrenocorticotropic hormone (ACTH) …

Social play is pervasive in juvenile mammals, yet it is poorly understood in terms of its
underlying brain mechanisms. Specifically, we do not know why young animals are most …