Molecular genetics of abnormal redox homeostasis in type 2 diabetes mellitus

I Azarova, A Polonikov, E Klyosova - International Journal of Molecular …, 2023 - mdpi.com
Numerous studies have shown that oxidative stress resulting from an imbalance between
the production of free radicals and their neutralization by antioxidant enzymes is one of the …

Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy

Y Dong, Q Zhao, Y Wang - Scientific reports, 2021 - nature.com
To explore the mechanism of the Astragalus membranaceous (AM)-Angelica sinensis (AS)
compound in the treatment of diabetic nephropathy (DN) we used network pharmacology …

Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways

R Hasan, S Lasker, A Hasan, F Zerin, M Zamila… - Scientific reports, 2020 - nature.com
The antidiabetic drug canagliflozin is reported to possess several cardioprotective effects.
However, no studies have investigated protective effects of canagliflozin in isoprenaline …

Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK–Akt–eNOS pathway in the isoprenaline-induced oxidative stress model

R Hasan, S Lasker, A Hasan, F Zerin, M Zamila… - Scientific Reports, 2020 - nature.com
Diabetes is a leading cause of chronic kidney disease, and the high prevalence of
sympathetic nervous system (SNS) hyperactivity in diabetic patients makes them further …

Chitosan-stabilized selenium nanoparticles alleviate cardio-hepatic damage in type 2 diabetes mellitus model via regulation of caspase, Bax/Bcl-2, and Fas/FasL …

AAR Mohamed, SI Khater, AH Arisha, MMM Metwally… - Gene, 2021 - Elsevier
The present study was carried out to explore a novel strategy with the hypothesis that the
combined treatment with standard antidiabetic drug metformin (MET) and chitosan stabilized …

Chitosan-stabilized selenium nanoparticles and metformin synergistically rescue testicular oxidative damage and steroidogenesis-related genes dysregulation in high …

YM Abd El-Hakim, A Abdel-Rahman Mohamed… - Antioxidants, 2020 - mdpi.com
Background: this study examined the metformin (MF) and/or chitosan stabilized selenium
nanoparticles (CH-SeNPs) efficacy to alleviate the male reproductive function impairment in …

Dapagliflozin ameliorates cognitive impairment in Aluminum-chloride-induced Alzheimer's disease via modulation of AMPK/mTOR, oxidative stress and glucose …

WA Samman, SM Selim, HM El Fayoumi, NM El-Sayed… - Pharmaceuticals, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurological illness characterized by memory loss
and cognitive deterioration. Dapagliflozin was suggested to attenuate the memory …

Moringa oleifera Lam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies

S Adarthaiya, A Sehgal - Phytotherapy Research, 2024 - Wiley Online Library
The metabolic syndrome (MetS) refers to the co‐occurrence of risk factors, including
hyperglycaemia, increased body weight, hypertension and dyslipidemia, which eventually …

Canagliflozin protects diabetic cardiomyopathy by mitigating fibrosis and preserving the myocardial integrity with improved mitochondrial function

D Dasari, SG Goyal, A Penmetsa, D Sriram… - European Journal of …, 2023 - Elsevier
Sodium-glucose transport protein 2 (SGLT-2) inhibitors are approved antidiabetic drugs with
a beneficial effect on reducing major adverse cardiac events and heart failure …

Hepatoprotective Potential of Sargassum muticum against STZ‐Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway

MM Safhi, MF Alam, SM Sivakumar… - Analytical cellular …, 2019 - Wiley Online Library
Liver inflammation and necrosis are the foremost problems interlinked with diabetes mellitus
(DM). The methanolic extract of Sargassum muticum (MESM) plays a hepatoprotective role …