[HTML][HTML] Neurotoxic agent-induced injury in neurodegenerative disease model: Focus on involvement of glutamate receptors
Glutamate receptors play a crucial role in the central nervous system and are implicated in
different brain disorders. They play a significant role in the pathogenesis of …
different brain disorders. They play a significant role in the pathogenesis of …
[HTML][HTML] Update on the treatment of ataxia: medication and emerging therapies
SL Perlman - Neurotherapeutics, 2020 - Elsevier
While rehabilitation therapies always help patients with ataxia, there are currently no FDA-
approved treatments for ataxia. Medications are available to treat symptoms that may …
approved treatments for ataxia. Medications are available to treat symptoms that may …
Maternal exposure to the CB1 cannabinoid agonist WIN 55212–2 produces robust changes in motor function and intrinsic electrophysiological properties of cerebellar …
The cerebellum, which controls coordinated and rapid movements, is a potential target for
the deleterious effects of drugs of abuse including cannabis (ie marijuana, cannabinoids) …
the deleterious effects of drugs of abuse including cannabis (ie marijuana, cannabinoids) …
Azo food dye neurotoxicity in rats: A neurobehavioral, biochemical, and histopathological study
Abstract Azo Food dyes (AFDs), which are widely used in the food industry, may be
associated with adverse health effects. We have investigated the effects of the AFDs metanil …
associated with adverse health effects. We have investigated the effects of the AFDs metanil …
Dental pulp stem cell transplantation ameliorates motor function and prevents cerebellar atrophy in rat model of cerebellar ataxia
Cerebellar ataxias (CA) include a range of neurodegenerative disorders hallmarked by
deterioration of the cerebellum. Cell replacement therapy (CRT) offers a potential remedy for …
deterioration of the cerebellum. Cell replacement therapy (CRT) offers a potential remedy for …
[HTML][HTML] The ameliorative effect of empagliflozin in vigabatrin-induced cerebellar/neurobehavioral deficits: targeting mTOR/AMPK/SIRT-1 signaling pathways
Introduction. Vigabatrin (VGB) is an antiepileptic drug that acts to irreversibly inhibit the γ-
aminobutyric acid (GABA) transaminase enzyme, elevating GABA levels. Broad studies …
aminobutyric acid (GABA) transaminase enzyme, elevating GABA levels. Broad studies …
[HTML][HTML] TGF-β1 provides neuroprotection via inhibition of microglial activation in 3-acetylpyridine-induced cerebellar ataxia model rats
BB Cao, XX Zhang, CY Du, Z Liu, YH Qiu… - Frontiers in …, 2020 - frontiersin.org
Cerebellar ataxias (CAs) consist of a heterogeneous group of neurodegenerative diseases
hallmarked by motor deficits and deterioration of the cerebellum and its associated …
hallmarked by motor deficits and deterioration of the cerebellum and its associated …
Reduction of glutamate neurotoxicity: A novel therapeutic approach for Niemann-Pick disease, type C1
A Cougnoux, JC Yerger, M Fellmeth… - Molecular genetics and …, 2021 - Elsevier
Niemann-Pick disease, type C1 is a progressive, lethal, neurodegenerative disorder due to
endolysosomal storage of unesterified cholesterol. Cerebellar ataxia, as a result of …
endolysosomal storage of unesterified cholesterol. Cerebellar ataxia, as a result of …
Differential effects of inferior olive lesion on vestibulo-ocular and optokinetic motor learning
The combined operation of optokinetic reflex (OKR) and vestibular-ocular reflex (VOR) is
essential for image stability during self-motion. Retinal slip signals, which provide neural …
essential for image stability during self-motion. Retinal slip signals, which provide neural …
Evidence for a common pharmacological interaction site on KCa2 channels providing both selective activation and selective inhibition of the human KCa2. 1 subtype
C Hougaard, S Hammami, BL Eriksen… - Molecular …, 2012 - ASPET
We have previously identified Ser293 in transmembrane segment 5 as a determinant for
selective KCa2. 1 channel activation by GW542573X (4-(2 …
selective KCa2. 1 channel activation by GW542573X (4-(2 …