Molecular mechanisms and physiological importance of circadian rhythms
A Patke, MW Young, S Axelrod - Nature reviews Molecular cell biology, 2020 - nature.com
To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
Transcriptional architecture of the mammalian circadian clock
JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder
A Patke, PJ Murphy, OE Onat, AC Krieger, T Özçelik… - Cell, 2017 - cell.com
Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes∼
24 hr rhythms in many behavioral and physiological processes. This system is altered in …
24 hr rhythms in many behavioral and physiological processes. This system is altered in …
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals
The mammalian circadian clock involves a transcriptional feed back loop in which CLOCK
and BMAL1 activate the Period and Cryptochrome genes, which then feedback and repress …
and BMAL1 activate the Period and Cryptochrome genes, which then feedback and repress …
Molecular mechanism of the repressive phase of the mammalian circadian clock
The mammalian circadian clock consists of a transcription–translation feedback loop (TTFL)
composed of CLOCK–BMAL1 transcriptional activators and CRY–PER transcriptional …
composed of CLOCK–BMAL1 transcriptional activators and CRY–PER transcriptional …
Macromolecular assemblies of the mammalian circadian clock
The mammalian circadian clock is built on a feedback loop in which PER and CRY proteins
repress their own transcription. We found that in mouse liver nuclei all three PERs, both …
repress their own transcription. We found that in mouse liver nuclei all three PERs, both …
Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver
The mammalian circadian clock uses interlocked negative feedback loops in which the
heterodimeric basic helix-loop-helix transcription factor BMAL1/CLOCK is a master …
heterodimeric basic helix-loop-helix transcription factor BMAL1/CLOCK is a master …
Regulation of circadian clock transcriptional output by CLOCK: BMAL1
AJ Trott, JS Menet - PLoS genetics, 2018 - journals.plos.org
The mammalian circadian clock relies on the transcription factor CLOCK: BMAL1 to
coordinate the rhythmic expression of 15% of the transcriptome and control the daily …
coordinate the rhythmic expression of 15% of the transcriptome and control the daily …
Clocks not winding down: unravelling circadian networks
An intrinsic clock enables an organism to anticipate environmental changes and use energy
sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock …
sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock …
Molecular genetic analysis of circadian timekeeping in Drosophila
PE Hardin - Advances in genetics, 2011 - Elsevier
A genetic screen for mutants that alter circadian rhythms in Drosophila identified the first
clock gene—the period (per) gene. The per gene is a central player within a transcriptional …
clock gene—the period (per) gene. The per gene is a central player within a transcriptional …