Aggression and violence represent a significant public health concern and a clinical
challenge for the mental healthcare provider. A great deal has been revealed regarding the …

The hypothalamic-pituitary-adrenal (HPA) axis is a major component of the systems that
respond to stress, by coordinating the neuroendocrine and autonomic responses. Tightly …

The neurotransmitter serotonin is an evolutionary ancient molecule that has remarkable
modulatory effects in almost all central nervous system integrative functions, such as mood …

Atavistic residues of aggressive behavior prevailing in animal life, determined by
testosterone, remain attenuated in man and suppressed through familial and social …

The serotonin system plays an important role in the neural processing of anxiety. The
involvement of the main inhibitory serotonergic receptor, the serotonin-1A (5-HT1A) subtype …

Brain serotonergic circuitries interact with other neurotransmitter systems on a multitude of
different molecular levels. In humans, as in other mammalian species, serotonin (5-HT) …

The inverse relation between serotonin and human aggression is often portrayed as
“reliable,”“strong,” and “well established” despite decades of conflicting reports and widely …

Serotonin (5-HT) is an ancient molecule directing behavioural responses to environmental
stimuli. The social environment is the most powerful environmental factor. It is well …

The hypothesis of chronically low brain serotonin levels as pathophysiologically linked to
impulsive aggression has been around for several decades. Whereas the theory was initially …

Aggression brings tremendous costs to individuals, relationships, and society. Yet, people
behave aggressively toward strangers and close others at alarmingly high rates. The current …