Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

M Maeki, N Kimura, Y Sato, H Harashima… - Advanced drug delivery …, 2018 - Elsevier
Lipid-based nanobiomaterials as liposomes and lipid nanoparticles (LNPs) are the most
widely used nanocarriers for drug delivery systems (DDSs). Extracellular vesicles (EVs) and …

[HTML][HTML] Separation and purification of biomacromolecules based on microfluidics

FA Vicente, I Plazl, SPM Ventura, P Žnidaršič-Plazl - Green chemistry, 2020 - pubs.rsc.org
Separation and purification of biomacromolecules either in biopharmaceuticals and fine
chemicals manufacturing, or in diagnostics and biological characterization, can substantially …

Progress of crystallization in microfluidic devices

H Shi, Y Xiao, S Ferguson, X Huang, N Wang, H Hao - Lab on a Chip, 2017 - pubs.rsc.org
Microfluidic technology provides a unique environment for the investigation of crystallization
processes at the nano or meso scale. The convenient operation and precise control of …

[HTML][HTML] Recent advances in X-ray compatible microfluidics for applications in soft materials and life sciences

A Ghazal, JP Lafleur, K Mortensen, JP Kutter, L Arleth… - Lab on a Chip, 2016 - pubs.rsc.org
The increasingly narrow and brilliant beams at X-ray facilities reduce the requirements for
both sample volume and data acquisition time. This creates new possibilities for the types …

[HTML][HTML] Protein crystallization in a droplet-based microfluidic device: Hydrodynamic analysis and study of the phase behaviour

J Ferreira, F Castro, F Rocha, S Kuhn - Chemical Engineering Science, 2018 - Elsevier
This work reports a cheap and easy-to-use droplet-based microfluidic platform for the study
of protein crystallization, offering the possibility to characterize the protein phase behaviour …

[HTML][HTML] Graphene-based microfluidics for serial crystallography

S Sui, Y Wang, KW Kolewe, V Srajer, R Henning… - Lab on a Chip, 2016 - pubs.rsc.org
Microfluidic strategies to enable the growth and subsequent serial crystallographic analysis
of micro-crystals have the potential to facilitate both structural characterization and dynamic …

[HTML][HTML] Microfluidics for multiscale studies of biomolecular condensates

NA Erkamp, R Qi, TJ Welsh, TPJ Knowles - Lab on a Chip, 2023 - pubs.rsc.org
Membraneless organelles formed through condensation of biomolecules in living cells have
become the focus of sustained efforts to elucidate their mechanisms of formation and …

[HTML][HTML] Room-temperature crystallography using a microfluidic protein crystal array device and its application to protein–ligand complex structure analysis

M Maeki, S Ito, R Takeda, G Ueno, A Ishida, H Tani… - Chemical …, 2020 - pubs.rsc.org
Room-temperature (RT) protein crystallography provides significant information to elucidate
protein function under physiological conditions. In particular, contrary to typical binding …

Advancements in macromolecular crystallography: From past to present

I Rathore, V Mishra, P Bhaumik - Emerging Topics in Life …, 2021 - portlandpress.com
Protein Crystallography or Macromolecular Crystallography (MX) started as a new discipline
of science with the pioneering work on the determination of the protein crystal structures by …

[HTML][HTML] Microfluidics: From crystallization to serial time-resolved crystallography

S Sui, SL Perry - Structural Dynamics, 2017 - pubs.aip.org
Capturing protein structural dynamics in real-time has tremendous potential in elucidating
biological functions and providing information for structure-based drug design. While time …