Skin conditions are numerous and often have a major impact on patients' quality of life, and
effective and safe treatment is very important. The conventional drugs used for skin diseases …

Chronic inflammatory skin diseases are multifactorial diseases that combine genetic
predisposition, environmental triggers, and metabolic disturbances associated with …

Background To date, there are no accepted outcome measures to monitor morphea, and
consensus on specific monitoring criteria for morphea remains elusive. A few studies have …

This review discusses the potential of targeting the kynurenine pathway (KP) in the treatment
of inflammatory diseases. The KP, responsible for the catabolism of the amino acid …

Introduction Methotrexate (MTX) is a folic acid antagonist used in clinical practice in
oncology and rheumatology, as well as in the treatment of inflammatory skin conditions in …

Morphea, also known as localized scleroderma, is an autoimmune chronic connective tissue
disease. It is characterized by excessive collagen deposition in the dermis and/or …

The genus Borrelia encompasses a diverse group of spirochetes transmitted primarily by
ticks, with Borrelia burgdorferi causing Lyme disease, which is prevalent in North America …

Localized scleroderma (LS), commonly known as morphea, presents a significant clinical
challenge due to its chronic, inflammatory nature affecting the skin and potentially …

Anti-synthetase syndrome (AS) is a subset of idiopathic inflammatory myopathy (IIM)
characterized by the presence of anti-aminoacyl-transfer RNA synthetase accompanied by …

Objectives: There is an under recognition of juvenile-onset localized scleroderma and its
extracutaneous manifestations leading to delay in systemic treatment. Our study aims to …