Despite years of active research into the role of DNA repair and replication in mutagenesis,
surprisingly little is known about the origin of spontaneous human mutation in the germ line …

Predicting evolutionary outcomes is an important research goal in a diversity of contexts.
The focus of evolutionary forecasting is usually on adaptive processes, and efforts to …

Approximately 13% of the human genome can fold into non-canonical (non-B) DNA
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …

Identifying genomic regions underlying adaptation in extant lineages is key to understanding
the trajectories along which biodiversity evolves. However, this task is complicated by …

De novo mutations occur at substantially different rates depending on genomic location,
sequence context and DNA strand. The success of methods to estimate selection intensity …

Biological mechanisms underlying human germline mutations remain largely unknown. We
statistically decompose variation in the rate and spectra of mutations along the genome …

Mutations drive evolution and were assumed to occur by chance: constantly, gradually,
roughly uniformly in genomes, and without regard to environmental inputs, but this view is …

Caenorhabditis nematodes form an excellent model for studying how the mode of
reproduction affects genetic diversity, as some species reproduce via outcrossing whereas …

It has long been suspected that the rate of mutation varies across the human genome at a
large scale based on the divergence between humans and other species. However, it is now …

Functionally indispensable genes are likely to be retained and otherwise to be lost during
evolution. This evolutionary fate of a gene can also be affected by factors independent of …