Replication fork collision with a DNA nick can generate a one-ended break, fostering
genomic instability. The opposing fork's collision with the nick could form a second DNA end …

Tandem duplications (TD) are among the most frequent type of structural variant (SV) in the
cancer genome. They are characterized by a single breakpoint junction that defines the …

Proper chromatin remodeling is crucial for many cellular physiological processes, including
the repair of DNA double-strand break (DSB). While the mechanism of DSB repair is well …

Replisome collision with a nicked parental DNA template can lead to the formation of a
replication-associated double strand break (DSB). How this break is repaired has …

Deciphering the fate of replication-induced DNA double-strand breaks: Molecular Cell Skip to
Main Content Skip to Main Menu Advertisement Molecular Cell This journal offers authors two …

DNA double-strand breaks (DSBs) are predominantly resolved by the error-prone non-
homologous end-joining (NHEJ) or high-fidelity homologous recombination (HR) DNA …

Genomic instability is a hallmark of cancer that can be caused by various forms of DNA
replication stress. Collision of the replication fork with obstacles ahead of the replication …